A Systematic Review of Pharmacological Interventions for Apathy in Aging Neurocognitive Disorders

Objective: Apathy, a frequent neuropsychiatric symptom in aging neurocognitive disorders, has been associated with cognitive decline and functional disability. Therefore, timely provision of pharmacological interventions for apathy is greatly needed. Design: A systematical literature review existing studies was conducted up to 30 May 2023 several databases (PubMed, PsychInfo, Cochrane, Google Scholar, etc.) that included randomized controlled trials (RCTs) meta-analyses assessing treatments disorders. The quality the appraised. Results: In patients Alzheimer’s Disease (AD), donepezil, galantamine, rivastigmine, methylphenidate, gingko biloba were proven efficacious apathy, while enhancer IRL752 piribedil found be beneficial Parkinson’s (PD) agomelatine Frontotemporal Dementia (FD). extensive proportion RCTs which used as secondary outcome measure, along considerable methodological heterogeneity, did not allow evaluation group effects. Conclusions: Pharmacological disorders are complex under-investigated. continuation systematic research efforts individualized treatment suffering from these vital.